Gerhard Levy, J. Procknal
Aug 1, 1968
Citations
0
Influential Citations
130
Citations
Quality indicators
Journal
Journal of pharmaceutical sciences
Abstract
Co-administration of salicylamide (SAM) and sodium salicylate to healthy adult humans resulted in a pronounced decrease in the formation of the glucuronides of these two drugs. This is thought to be due to a limited capacity for glucuronide conjugation in man and/or to the uncoupling action of salicylate on oxidative phosphorylation. Salicylate may inhibit also the formation of SAM sulfate; it has no effect on the excretion rate constants of SAM glucuronide and SAM sulfate in the doses used in the investigation. The results of this study indicate that concomitant use of certain drugs which are readily available to the public may lead to appreciable interactions in biotransformation and to enhanced pharmacologic effects.