T. Mei, Dong-Hui Wang, jin-quan yu
Jun 15, 2010
Citations
0
Influential Citations
121
Citations
Quality indicators
Journal
Organic letters
Abstract
Pd(II)-catalyzed ortho-C-H iodination reactions of phenylacetic acid substrates have been achieved using recyclable PdI(2) as the precatalyst. This class of substrates is incompatible with the classic amide formation/ortho-lithiation/iodination sequence. The power of this new technology is demonstrated by facile drug functionalization and drastically shortened syntheses of the drugs diclofenac and lumiracoxib.