Yanxue Liu, Yuheng Zong, Zixuan Yang
Jan 15, 2019
Citations
1
Influential Citations
28
Citations
Journal
ACS Sustainable Chemistry & Engineering
Abstract
Dihydroartemisinin (DHA) as an effective anticancer drug is being concerned owing to the excellent efficacy, but the poor solubility and premature release confine the clinical application. Construction of a satisfied DHA-loaded delivery system with targeted recognition and specific controlled release brings opportunities and challenges, which can be triggered through an endogenous stimulus. In this work, we designed a traceable and dual-targeted DHA-loaded nanocarrier by taking advantage of the highly expression of pectin with galactose residues to asialoglycoprotein receptors on the surface of liver, as well as the highly expression of folic acid (FA) to folic acid receptors. Folic acid modified pectin was coupled with DHA-loaded eight-arm polyethylene glycol conjugates to prepare folic acid-pectin-eight-arm polyethylene glycol-dihydroartemisinin prodrugs (FA-Pectin-8armPEG-DHA), and then embedded hydroxycamptothecin by the self-assembly of hydrophobic drugs and hydrophilic carriers to prepare folic acid...