Y. Mori, T. Niwa, K. Toyoshi
May 23, 1981
Citations
0
Influential Citations
12
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Twenty azobenzene derivatives structurally related to 3'-hydroxymethyl-4-(dimethylamino) azobenzene (3'-CH2OH-DAB) were synthesized for the purpose of investigating their mutagenic and carcinogenic effects. They are oxidation products of 3'-Me-DAB, symmetrically substituted azo compounds, their acetyl or chloro derivatives, and their isomers. The 4-(dimethylamino) azobenzenes were prepared by coupling of the corresponding diazonium salts with N, N-dimethylaniline and the azobenzenes by reduction of the corresponding nitrobenzenes with lithium aluminum hydride or zinc in a sodium hydroxide medium. Physical characteristics of these compounds (melting point, elemental analysis, and infrared, ultraviolet, and mass spectral data) are given.