A. Ammazzalorso, R. Amoroso, G. Bettoni
May 16, 2004
Citations
0
Influential Citations
7
Citations
Journal
Arkivoc
Abstract
The conversion of racemic α-bromobutanoic acid into the corresponding esters with amides of (S)-lactic acid as chiral auxiliaries was examinated. Displacement of the bromine with 4chlorophenoxide, under suitable reaction conditions, was found to proceed with good to high diastereoselectivity to give 4-(chlorophenoxy)butanoyl esters. After hydrolysis, the (R)enantiomer of antilipidemic 2-(4-chlorophenoxy)butanoic acid was obtained.