A. Kubo, M. Takahashi, H. Kubota
Aug 28, 1995
Citations
0
Influential Citations
14
Citations
Journal
Tetrahedron Letters
Abstract
Dynamic kinetic resolution by highly stereoselective carbon-carbon bond formation utilizing 2-oxoimidazolidine-4-carboxylate as a chiral auxiliary was exploited. The reaction of tert-butyl(4S)-1-methyl-3-(2-bromopropionyl)-2-oxoimidazolidine-4-carboxylate (1) with sodium dimethyl malonate in HMPA at room temperature predominantly afforded tert-butyl(4S)-1-methyl-3-((2R)-2-methyl-3,3-bis(methoxycarbonyl)propionyl)-2-oxoimidazolidine-4-carboxylate ((S,R)-2a) in a good yield.