E. Andrianova, M. A. Petrovskaya, M. B. Petrova
2020
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Journal
Современные проблемы науки и образования (Modern Problems of Science and Education)
Abstract
Study In an experiment on rats, the effectiveness of using a new derivative of N-acetyl-6-aminohexanoic (acexamic) acid in the healing burn wounds was studied. At the same time the dynamics of oxidative stress indicators at the stages of the wound healing process on 7, 14 and 21 days of investigation were assessed. Animals of three groups (without treatment of wounds, with applying only an ointment base and applying 2% ointment of a new derivative of N-acetyl-6-aminohexanoic acid) after experimental modeling of thermal burn, carried out a planimetric assessment of wounds and determining the levels of oxidative stress indicators – the total total oxidative and antioxidant activity of blood serum and homogenates of regenerating tissues by photometric method, calculated the index of oxidative stress as a ratio of the abovementioned indicators. The study has shown that the new derivative N-acetyl-6-aminohexanoic acid 2% ointment has proregenerative properties, manifested in statistically significant acceleration of healing of experimental thermal burns and decrease oxidative stress in the regenerating tissues and blood of animals of the main group compared with rats of control groups. It was found inflammation and proliferation of skin defect regeneration. The revealed restoration of the balance of metabolites with oxidant and antioxidant properties indicates a decrease in the activity of free radical processes, which are one of the pathogenetic mechanisms of burn damage. The obtained results serve as a pathogenetic justification for correcting the reparative process using a new acexamic acid derivative in order to establish indications and contraindications for its application.