M. Gouda, A. Abu‐Hashem
Mar 8, 2012
Citations
0
Influential Citations
30
Citations
Journal
Green Chemistry Letters and Reviews
Abstract
Abstract Commercially available lithium hydroxide monohydrate (LiOH·H2O) was found to be a novel “dual activation” catalyst for Knoevenagel condensation between malononitrile (1) or 3-methyl 1-phenyl-1H-pyrazol-5-(4H)-one (6) with aromatic aldehydes 2a–e leading to an efficient and easy synthesis of arylidenemalononitriles 3a–d and 4,4′-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) 7a–c in short times. The reaction of aryl aldehydes with malononitrile afforded excellent yields after 1–6 min in aqueous media at room temperature. In case of 3-methyl-1-phenyl-1H-pyrazol-5-(4H)-one (6) and aromatic aldehydes afforded good yields after 60–75 min at 90°C.