J. Suh
May 1, 2004
Citations
2
Influential Citations
30
Citations
Journal
Expert Opinion on Investigational Drugs
Abstract
Efaproxiral (RSR13) is a synthetic allosteric modifier of haemoglobin that reduces its oxygen binding affinity. By facilitating the release of oxygen from haemoglobin, efaproxiral causes an increase in whole blood P50 (partial pressure of oxygen which results in 50% haemoglobin saturation) and an increase in the Po2 (partial pressure of oxygen) in the tissue. The therapeutic strategy of enhancing oxygen unloading from haemoglobin to tissue emulates and amplifies physiological tissue oxygenation and can enhance the oxygenation of hypoxic tumours. Since hypoxia is known to decrease the effectiveness of radiation therapy, the use of efaproxiral as a radiation sensitiser may be advantageous. Unlike previous radiation sensitisers, efaproxiral does not need to enter the cancer cells to increase radiosensitivity. Phase I – III trial data have defined the safety profile and dosing of the drug, with the potential benefit for extended survival.