R. Bridges, J. Ricketts
May 1, 1968
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
Comparative biochemistry and physiology
Abstract
Abstract 1. 1. Retardation of the growth of Musca domestica larvae by 2-amino-butan-1-ol, 2-amino-2-methylpropan-1-ol and a number of their N-alkyl-derivatives has been studied. 2-Aminobutan-1-ol was the most active compound in this respect. 2. 2. Choline was effective in reversing this retardation when included in the larval diet at a considerably lower concentration than that of the aminobutanols. A number of compounds related to choline were also capable of reversing the growth retardation, although none were as effective as choline. 3. 3. The majority of the aminobutanols studied were incorporated into the phospholipids of the larvae. 4. 4. Formation of considerable amounts of phosphoryl-2-aminobutan-1-ol and an increase in the phosphorylcholine concentration was demonstrated in larvae fed on diets containing 2-aminobutan-1-ol. 5. 5. The antagonistic effect of the aminobutanols and choline in the housefly is discussed and the results compared with studies carried out with vertebrates.