M. Challiner, B. Park, J. Odum
Aug 1, 1981
Citations
0
Influential Citations
10
Citations
Quality indicators
Journal
Biochemical pharmacology
Abstract
Abstract The effect of 3-methylcholanthrene treatment on the urinary excretion of 6β-hydroxycortisol and hepatic enzyme activity was investigated in the marmoset monkey ( Callithrix jacchus ). 3-Methylcholanthrene increased cytochrome P-448 content, NADPH cytochrome- c reductase activity, 7-ethoxy-coumarin O -deethylase activity and ethoxyresorufin O -deethylase but did not affect aminopyrine N -demethylase activity. This induction profile is qualitatively similar to that previously reported for the rat. There was no change in the ratio of urinary 6β-hydroxycortisol to 17-hydroxycorticosteroids. The pattern of response to 3-methylcholanthrene indicates that cortisol 6β-hydroxylase activity is not associated with induction of hepatic cytochrome P-448.