Nie Zheng
2008
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Journal
Journal of Modern Oncology
Abstract
Objective:To approach the effect of Racanisodamine in the preservation of flap necrosis after breast surgery.Methods: To divide randomly 312 patients with modified radical mastectomy into two goups.The patients in group A were administrated racanisodamine 20mg/kg and 0.9% sodium chloride through micro pump every day as experimental group,and those in group B were treated with common mathad as control group.Both two groups included patients operated with transverse or longitudinal incision.Compared the incidence of flap necrosis between 2 groups.Results: There were 22 cases apearing flap necrosis among 176 cases of group A(12.5%),while 36 cases apeared flap necrosis among 136 cases of group B(26.4%).No matter which kind of incision were applied,the incidence of flap necrosis was lower in experimental group than control group and the difference was statistically significant(P0.05).In respective groups,the incidence of flap necrosis was lower in the patients applied transverse incision than longitudinal incision but the difference was not statistically significant(P0.05).Conclusion: Racanisodamine is a protective factor of flap necrosis.Longitudinal incision is tend to lead to flap necrosis.