D. Lathia, U. Frentzen
1980
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Food and cosmetics toxicology
Abstract
Abstract The rate of formation of N -methyl- N -nitrosoaniline (NMNA) from nitrite and N -methylaniline in the presence of chlorogenic acid and/or thiocyanate at levels likely to be encountered in vivo was studied in a series of in vitro reactions. Chlorogenic acid, a phenolic component of coffee, had a marked catalytic effect, which was directly related to its concentration. Thiocyanate also catalysed NMNA formation, and together the two compounds had a cumulative effect on the reaction although in the presence of a constant level of thiocyanate, the increase in NMNA yield was indirectly proportional to the chlorogenic acid concentration.