D. Cusi, R. Garay
May 1, 1981
Citations
1
Influential Citations
16
Citations
Quality indicators
Journal
Molecular pharmacology
Abstract
Tienilic acid inhibits erythrocyte Na + ,K + cotransport to a lesser extent than does furosemide. This property seems to be proportional to its diuretic effects. Under conditions in which the erythrocytes have all of their saturable Na + and K + transport systems blocked, the addition of tienilic acid induces an increase in K + permeability. This effect shows saturation kinetics with the increase in the internal K + concentration and could not be inhibited by ethylene glycol bis(β-aminoethyl ether)- N,N,N9,N9 -tetraacetic acid quinine, carbocyanine, or tetraethylammonium. These results suggest that the main effects of tienilic acid on transmembrane cation transport may be the opening of transient or permanent K + channels.