F. Lembeck, K. Folkers, J. Donnerer
Dec 31, 1981
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0
Influential Citations
97
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Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
[D-Pro2,D-Phe7,D-Trp9]-SP and [D-Pro2,D-Trp7,9]-SP havebeen shown to be antagonists of substance P. The hindlimb scratching syndrome of mice, known to be caused by substance P was absent when these peptides were injected into substance P-treated mice. Substance P shortens “tail withdrawal time” from hot water; the two peptides greatly prolonged tail withdrawal time. Antidromic stimulation of the saphenous nerve (rat), known to release substance P and to induce vasodilatation plasma extravasation, was also greatly inhibited by [D-Pro2,D-Phe7,D-Trp9]-SP. These peptides presumably cause anti-nociceptor effects (analgesia) by inhibition of substance P at receptors and favor the concept that substance P is a sensory neurotransmitter of nociceptive messages.