K. Kamiya, W. Hamabe, S. Tokuyama
Feb 1, 2010
Citations
3
Influential Citations
52
Citations
Quality indicators
Journal
Food Chemistry
Abstract
Abstract During the course of our studies to develop new uses for the Noni ( Morinda citrifolia ) root, 10 anthraquinones, rubiadin ( 1 ), rubiadin 1-methyl ether ( 2 ), lucidin ( 3 ), damnacanthol ( 4 ), 1,3-dihydroxy-2-methoxymethylanthraquinone ( 5 ), 3-hydroxy-1-methoxy-2-methoxymethylanthraquinone ( 6 ), nordamnacanthal ( 7 ), damnacanthal ( 8 ), sorandidiol ( 9 ) and morindone ( 10 ), were isolated. Compounds 5 , 6 , 7 , 8 and 10 exhibited remarkable inhibition against the activities of animal pols, and compound 10 was the strongest inhibitor in the anthraquinones investigated. Among mammalian pols, compound 10 inhibited the pol activities of A- (pol γ), B- (pols α, δ and e) and Y- (pols η, ι and κ) families, but did not influence the activities of X-family pols (pols β, λ and terminal deoxynucleotidyl transferase). The tendency of pol inhibition showed a positive correlation with the suppression of human colon cancer cell HCT116 growth. These results suggested that the Noni root containing anthraquinones may be used as an anticancer functional food.