J. W. Barnhart
Feb 1, 1974
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract The effect of chlorcyclizine, a known hypocholesterolemic agent, on cholesterol metabolism in mice was reexamined. The reduction of serum cholesterol and increase in liver weight and total cholesterol after chlorcyclizine treatment were confirmed. After a single ip injection of chlorcyclizine (50 mg/kg), a significant elevation of liver cholesterol was observed after 12 hr and a reduction of serum cholesterol was seen after 24 hr. The elevation of liver cholesterol was accounted for exclusively in the esterified fraction. Oral doses effective in reducing serum cholesterol were also effective in elevating liver esterified cholesterol. The incorporation of [ 14 C]acetate into cholesterol in vivo was not reduced after chlorcyclizine treatment, suggesting that cholesterol biosynthesis was not inhibited. A marked inhibition of steryl ester hydrolase was caused by chlorcyclizine in vitro. The large excess of cholesteryl esters in the liver was possibly a result of this effect.