He Tian-hu
2009
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Journal
Progress in Veterinary Medicine
Abstract
The purpose of this study was to investigate the cellular effects of cloprostenol sodium(PG-Cl) on the growth of SKOV3 cell lines of human ovarian cancer in vitro.The antitumor effect was studied using MTT assay,Giemsa staining assay,boold-cell counter system and hoechest-33324 cell staining assay.The results showed that the proliferation of SKOV3 cells was inhibited by PG-Cl in a dose and time dependent fashion,and was significant under high concentration.While cell apoptosis happened after 12 h in 150 μg/mL concentration.The fluorescent assay showed round and oval nuclei.It is speculated that PG-Cl may significantly inhibit the proliferation of SKOV3 cells,and induce cell apoptosis in vitro.