S. Yong
1998
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Quality indicators
Journal
Chinese Journal of Pharmaceuticals
Abstract
In cerebral ischemic rats daltroban (BM13,505,1)3.5,4.4 mg·kg-1 iv decreased the levels of LA, MDA in brain tissue (P0.01) and improved the electroencephalogram(EEG); 4.4 mg·kg-1 iv increased the activity of SOD in brain tissue (P0.05) 1 5,10 mg·kg-1 ip prolonged the time of gasping (P0.05) in decollated mice. 1 4 mg·kg-1 ip increased the survival rates of mice with tissular poisonous hypoxia (P0.05), and the ED50 of 1 on improving hypoxia was 4.45 mg·kg-1. The results suggested that 1 may have protective effect on experimental cerebral ischemia.