Guo Hui
1993
Citations
0
Influential Citations
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Citations
Journal
Chinese Journal of Pharmaceuticals
Abstract
Ethyl 7-chloro-6-fluoro-4-hydroxyquinoline-3-carboxylate (3) was subjected to ethylation with ethyl bromide in different solvents (including hydrous DMF) with anhydrous K_2CO_3 or Na_CO_3 to give mixed N-and O-ethylated pro- ducts(2 and 1).The ratio betwean 2 and 1 in the mixture was investigated by HPLC method.The result indicated that the relative content of 1 was signifi- cantly reduced with Na_2CO_3 and not affected by the water contained in DMF.