L. Xiaoxia
2011
Citations
1
Influential Citations
7
Citations
Quality indicators
Journal
Chinese Journal of Appplied Environmental Biology
Abstract
Erianin,a low molecular-weight natural product isolated from Dendrobium chrysotoxum Lind.,is often used as an anti-pyretic and an analgesic in traditional Chinese medicine.Herein,this study evaluated the erianin's effect on cell proliferation,apoptosis and cell cycle progression of hepatocellular carcinoma(HCC) Huh7 cancer cells especially.The results in vitro demonstrated that erianin significantly suppressed proliferation of Huh7 cancer cells in a dose-and time-dependent manner which was associated with induced apoptosis and cell cycle G2-M arrest,and the IC50 value was 37.4 nmol/L after 48 h exposure to erianin.Mechanistically,erianin could inhibit Akt activation,down-regulate the expression of Mcl-1 protein,and activate the cleavage of PARP in a dose-and time-dependent manner,leading to marked inhibitory effect of Huh7 cells.These findings suggest that erianin may be a promising antitumor drug for prevention and treatment of HCC.Fig 5,Ref 17