ZhongHua Lei, L. Ouyang, Yong Gong
Apr 29, 2020
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Drug Design, Development and Therapy
Abstract
Purpose The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis. Methods We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund’s complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats. Results ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells. Conclusion ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.