L. Pan
2012
Citations
1
Influential Citations
1
Citations
Quality indicators
Journal
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
Abstract
Objective To study the protective effect of Fasudil hydrochloride on postconditioning of acute myocardial ischemia reperfusion injury in rats.Methods Forty-eight SD rats were randomly divided into sham operation group,ischemia reperfusion group,ischemic postconditioning group, Fasudil hydrochloride group(12 in each group) and sacrificed 3 h after reperfusion.Their heart function,plasma myocardial enzyme,myocardial infarction and myocardial cell apoptosis were detected. Results The plasma myocardial enzyme level was significantly higher in ischemia reperfusion group,ischemic postconditioning group and Fasudil hydrochloride group than in sham operation group(P0.01).The heart function,plasma myocardial enzyme level,myocardial infarction and myocardial cell apoptosis were significantly lower in Fasudil hydrochloride group than in ischemia reperfusion group(P0.01).Conclusion Fasudil hydrochloride can mimic the ischemic postconditioning,alleviate myocardial ischemia reperfusion injury,reduce myocardial cell apoptosis and improve myocardial infarction.