Yang Wei
2013
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Central South Pharmacy
Abstract
Objective To investigate the analgesic effect of felbinac trometamol injection(FTI) on the single foot acute inflammation model and chronic inflammation model and analyze its active site.Methods Carageen glue induced by single foot inflammatory model of acute inflammation and complete freund’s adjuvant by single foot inflammatory model of chronic inflammation were used to determine the analgesic effect of FTI.Results In the single foot acute inflammation model and chronic rational model in rats,FTI(25.2 and 75.6 mg·kg-1) enhanced the pain threshold in the inflamed rat paws,but no significant changes were observed in that of the non-inflamed paws.The analgesic effect was equal to that of flurbiprofen acetate injection,but pentazocine injection enhanced the pain threshold in the inflamed and non-inflamed rat paws.Conclusion FTI has a significant peripheral analgesic effect to ease pain.