J. Massó, J. Conde, Á. Villar
Nov 1, 1993
Citations
0
Influential Citations
7
Citations
Quality indicators
Journal
Journal of Pharmacy and Pharmacology
Abstract
Abstract— Fepradinol is an effective non‐steroidal anti‐inflammatory agent. The effect on rat paw oedema induced by various phlogistic agents was investigated. The inhibitory effect of fepradinol (25 mg kg−1, p.o.) on dextran‐induced oedema was nearly equal to that of cyproheptadine (10 mg kg−1, p.o.). On oedema induced by platelet‐activating factor only fepradinol (25 mg kg−1, p.o.) and phenidone (100 mg kg−1, p.o.) clearly inhibited the inflammatory process. Both the above induced oedemas are thought to be unrelated to prostaglandins in the rat system and therefore, the anti‐inflammatory activity against them is not shared by selective cyclo‐oxygenase inhibitors. Fepradinol (25 mg kg−1, p.o.) displayed an inhibitory effect on the early and late stage of kaolin‐ and nystatin‐induced oedemas in contrast with indomethacin (10 mg kg−1, p.o.) and piroxicam (10 mg kg−1, p.o.) which only inhibited the late stage. The results obtained in this study confirm that fepradinol is a potent anti‐inflammatory agent and indicate that its mechanism of action is different from that of other anti‐inflammatory compounds.