H. McCann, F. Bullock
Jun 1, 1957
Citations
2
Influential Citations
62
Citations
Quality indicators
Journal
Journal of Dental Research
Abstract
7HE formation of fluorapatite in aqueous solution has been noted by MacIntire, Hardin, Oldham, and Hammond1 in studies of the cause of phosphate insolubility, by Montel and Chaudron,2 Rathje,3 in their studies on the synthesis of various apatites, and McCann4 in a study of the reactions of fluoride with hydroxyapatite. Neuman, Neuman, Main, O 'Leary, and Smith5 have shown that fluorapatite is formed below the solubility product of calcium fluoride by ionic exchange. McCann and Bullock6 indicated that a number of reactions occur between fluoride ion and powdered enamel and dentin, but the principal one, up to a concentration of about 100 ppm F-, is the formation of fluorapatite. Gerould,7 Syrrist,8 and Rathje9 have presented evidence showing that it is quite probable that the principal reaction occurring between fluoride and the hard tissues of the body in vivo is the formation of fluorapatite. It was the purpose of this studyto obtain additional evidence of the formation of fluorapatite in vivo in skeletal and dental tissues. Information was obtained also on the properties of tissues fluorosed in vivo as well as in vitro, as shown by solubility and ion-exchange studies. A chemical analysis of control and fluorosed tissues furnished additional data on the effect of fluoride on tissue composition.