Yang Fang
2007
Citations
0
Influential Citations
1
Citations
Quality indicators
Journal
Chinese Journal of Pharmacology and Toxicology
Abstract
AIM To explore effects of cyclov- irobuxine-D(CVB-D) on heart function and blood pressure of rats in vivo.METHODS CVB-D 3.35 mg·kg~(-1)·d~(-1) was given(ig) to male SD rats for 2,4 and 6 weeks,then pro- ceeded in vivo hemodynamic measurements through right carotid artery.Left ventricular systolic pressure(LVSP),left ventricular end- diastolic pressure(LVEDP),maximal rate of rise and decline of left ventricular pressure (±dp/dt_(max)),systolic blood pressure(SBP), diastolic blood pressure(DBP) and heart rate (HR) were detected by the Medlab 6 system. RESULTS No significant differences were observed in 2-week and 4-week groups.LVSP elevated notably in 6-week CVB-D group,while SBP decreased.LVEDP,±dp/dt_(max),DBP and HR stayed stable in two groups.CONCLU- SION CVB-D can improve heart function and lower blood pressure,while not quickening the heart rate synchronously.