A. Ganeshpurkar, A. Saluja
2018
Citations
1
Influential Citations
33
Citations
Quality indicators
Journal
International Immunopharmacology
Abstract
ABSTRACT The present study was focused on examining the effect of catechin on the cellular and humoral immunity in rat model. Immunomodulatory effect of catechin was determined by delayed‐type hypersensitivity (DTH) response, carbon clearance assay, leucocyte mobilization test and cyclophosphamide‐induced myelosuppression and hemagglutinating antibody (HA) titer assay. Catechin in experimental dose (25, 50 and 100 mg/kg, p.o.) elevated a significant increase in antibody titer in the hemagglutination test with increased levels of immunoglobulin. There was an enhancement in the delayed‐type hypersensitivity reaction produced by sheep red blood cells. There was also restoration in the functioning of leucocytes in cyclophosphamide‐treated rats with an increased clearance of carbon particles. The results of the present study signify that catechin possesses sufficient potential for modulating immune activity by cellular and humoral mechanisms. HighlightsCatechin elevated a significant increase in antibody titer.There was an enhancement in the delayed type hypersensitivity reaction.There was restoration in the functioning of leucocytes.Catechin possesses sufficient potential for increasing immune activity.