Richard McCandless, S. Yalkowsky
Dec 1, 1998
Citations
0
Influential Citations
21
Citations
Journal
Journal of Pharmaceutical Sciences
Abstract
Levemopamil was solubilized by varying the concentration of hydroxypropyl-β-cyclodextrin (HPβCD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HPβCD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HPβCD concentration of the charged and uncharged forms of the drug follows the AL and AP complexation models, respectively. This suggests that the charged drug forms a 1:1 complex, whereas the neutral drug forms both 1:1 and 1:2 complexes.