A. Morice, A. Marshall, K. Higgins
Oct 1, 1994
Citations
3
Influential Citations
130
Citations
Quality indicators
Journal
Thorax
Abstract
BACKGROUND Menthol is a commonly used ingredient in many over the counter cough remedies, but there is little objective evidence as to its efficacy. METHODS Twenty healthy subjects received a cough challenge consisting of five inhalations of 33 mumol citric acid from an air driven dosimeter. The challenge was repeated at hourly intervals for five hours. Five minutes before each challenge subjects inhaled, in a randomised design, either menthol 75% in eucalyptus oil or one of two placebos (pine oil or air). RESULTS Menthol inhalation caused a reduction in evoked cough when compared with either placebo. CONCLUSIONS Menthol is an effective antitussive agent in an evoked cough model.