Wafaa H Mohamed, K. Amein, D. Yahia
Apr 3, 2020
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
Journal of food biochemistry
Abstract
Imidacloprid, a systemic chloro-nicotinyl insecticide belong to neonicotinoid insecticides. In this study 120 rats were divided into four groups, the first group used as a control group, the second group was administered imidacloprid at a dose of 22.5 mg/kg b.w. for 4, 8, and 12 weeks. The third group was treated with olive oil (OLO) in a dose of 10 ml/kg body weight for 2 weeks before the oral dose of imidacloprid for 4, 8, and 12 weeks. The fourth group was given OLO in a dose of 10 ml/kg b.w. for 2 weeks after exposure to imidacloprid for 4, 8, and 12 weeks. Bone marrow was collected for micronucleus and chromosomal aberrations assays. The results revealed that imidacloprid induced a mutagenic effect in the 8th and 12th weeks of exposure and OLO decreased the mutagenic effect of imidacloprid in albino rats but not completely revert them to normal. PRACTICAL APPLICATIONS: Using OLO as a protective or therapeutic agent due to it has an ameliorative effect on mutagenicity induced by IMI.