Ma Shi-ping
2011
Citations
0
Influential Citations
5
Citations
Quality indicators
Journal
Pharmaceutical and Clinical Research
Abstract
Objective: To investigated the effect of isorhynchophylline on the release of inflammatory mediators in lipopolysaccharide(LPS) stimulated primary astrocytes.Methods: Isorhynchophylline at various concentrations was used to treat primary astrocytes with or without 1 μg·mL-1 LPS.Results: Isorhynchophylline potently depressed the expression level of iNOS mRNA and suppressed the production of IL-1β,TNF-αand NO.Conclusion: Isorhynchophylline effectively depresses the inflammation in CNS,which provide detail evidence for the usage of Uncaria rhynchophylla to treat brain ischemia disease.