A. Micov, M. Tomić, Božidar V. Popović
Sep 1, 2010
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Journal
British Journal of Pharmacology
Abstract
BACKGROUND AND PURPOSE Levetiracetam, a novel antiepileptic drug, has recently been shown to have antinociceptive effects in various animal models of pain. The purpose of this study was to investigate the antihyperalgesic effect of levetiracetam and its mechanism of action, by examining the involvement of GABAergic, opioidergic, 5‐hydroxytryptaminergic (5‐HTergic) and adrenergic systems in its effect, in a rat model of inflammatory pain.