Long-yun Li
2008
Citations
1
Influential Citations
21
Citations
Quality indicators
Journal
Journal of Emergency in Traditional Chinese Medicine
Abstract
Objective:To study the protective effect of lobetyolin on gastric mucosa of experimental gastric ulcer induced by ethanol in rats.Methods:The gastric ulcer model was established in rats by inducing ethanol.The index of ulcer was measured;the levels of Gas and 6-K-PGF1αwere examined by the method of radioimmunity;the level of EGF was measured by ELISA.Results:As compared with model group,in lobetyolin small dose group,the index of ulcer was markedly decreased,the level of Gas was decreased while the level of 6-K-PGF1αwas increased.In the degree,the level of EGF was increased.Conclusion:Lobetyolin has a protective role in gastric mucosa injury,and the mechanism may be relate to the increase in level of 6-K-PGF1αand the inhibition the excretion of gastric acid and EGF.