Selda Kargın Kaytez, Ali Kavuzlu, N. Yumuşak
Oct 30, 2018
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European Archives of Oto-Rhino-Laryngology
Abstract
ObjectivesIn this study, our aim was to identify the possible effects of montelukast sodium (ML) on the prevention of experimentally induced myringosclerosis.Materials and methodsTwenty-eight female Wistar albino rats were used and they were divided into four groups randomly. Tympanic membranes (TM) of all animals were perforated and then group 1 received no treatment (control group), group 2 was treated with a topical saline solution, group 3 received topically ML and group 4 received orally ML. On the 15th day, all animals were euthanized. Tympanic membranes were evaluated otomicroscopically and histopathologically.ResultsThe histopathological findings, compared against a control and saline groups, showed the topically and orally ML groups had statistically significant differences of degree of myringosclerosis (p < 0.002) and median thickness of the TMs (p < 0.001). Suppression of inflammation was statistically significant only in the oral ML treatment group (p < 0.002).ConclusionOral and topically administration of ML reduced myringosclerosis formation in myringotomies rats.