S. Ogawa, S. Okuyama, H. Araki
Sep 22, 1994
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0
Influential Citations
34
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Journal
European Journal of Pharmacology
Abstract
N,N-Dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) is a selective and potent σ receptor ligand. We investigated the effects of NE-100 on phencyclidine (PCP)-induced cognitive dysfunction in rats in a water maze task. NE-100 significantly shortened the PCP-induced prolonged swimming latency as did 1-(cyclopropylmethyl)-4-[2′(4″-fluorophenyl)-2′-oxoethyl]- piperidine monohydrobromide (Dup 734), 4-[2′-(4″-cyanophenyl)-2′-oxoethyl]-1-(cyclopropyl-methyl)piperidine (XJ 448), α-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol (BMY 14802) and rimcazole, all of which are σ receptor ligands and possibly antagonists. Ritanserin, a 5-HT2 receptor antagonist, also showed a tendency to shorten swimming latencies. Latencies of haloperidol-, cis-N-(1-benzyl-2-methyl-pyrrolidin-3-yl)-2-mrthoxy-5-chloro-4- methyl-aminobenzamide (YM-09151-2)- and sulpiride-, dopamine D2 receptor antagonists, treated groups did not differ from that seen in the PCP-treated group. Thus, PCP-induced cognitive dysfunciton may be improved by σ receptor ligands.