A. Niewiadomy, A. Skrzypek, J. Matysiak
Oct 1, 2010
Citations
0
Influential Citations
1
Citations
Journal
Journal of Liquid Chromatography & Related Technologies
Abstract
The retention behavior of compounds of antiproliferative activity from the 4-(5-amino-1,3,4-thiadiazol-2-yl)benzene-1,3-diols group by OPLC was investigated. RP-18 stationary phase and five different organic modifiers were used. In the case of ethanol as an organic solvent the highest concentration of water in the eluent can be applied. On the base of the linear relationship between the retention and the concentration of organic solvent, various lipophilicity descriptors were determined. Moderate correlations between the chromatographic parameters and the calculated log P values according to the Villar approach were found. The RMw parameters were compared with the antiproliferative activity of compounds against human cancer cell T47D (breast cancer) to find QSAR equations. The best results for ethanol as the organic solvent were found.