I. Barid, W. Sosroseno
Dec 1, 2002
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Influential Citations
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Quality indicators
Journal
Journal of oral science
Abstract
The aim of this study was to determine the effect of parachlorophenol (PCP) and camphorated parachlorophenol (CMCP) on nitric oxide (NO) production by a murine macrophage cell line, RAW264.7. The cells were incubated on plastic disks with either PCP or CMCP. Plastic adherent and nonadherent cells were subsequently stimulated with recombinant mouse IFN-gamma or bacterial lipopolysaccharide (LPS). Nitric oxide (NO) levels detected from the culture supernatants were determined by the Griess reaction. The results showed that PCP and CMCP diluted at 10(-1) but not at 10(-3) suppressed NO production by both plastic adherent and nonadherent cells, suggesting that both phenolic compounds may suppress NO production by murine macrophages in a dose-dependent manner.