J. Linsk, B. Paton, M. Persky
Mar 1, 1957
Citations
0
Influential Citations
13
Citations
Journal
The Journal of clinical endocrinology and metabolism
Abstract
INTRODUCTION PHENYLBUTAZONE is a pyrazalone derivative which has been shown to have effects similar to those of cortisone and corticotropin with respect to anti-rheumatic activity and sodium retention (1). In 1952 Green et at. demonstrated that, in addition to its other pharmacologic effects, phenylbutazone had a marked inhibiting action on the uptake of I131 by the thyroid (2); this followed the daily administration of 1 gram of the drug for two or three days. It was suggested by Scott et al. (3), on the basis of work in rats, that phenylbutazone combines with iodine in the body and thus prevents it from being taken up by the thyroid. It was also observed that, despite continuing administration of the drug, thyroidal iodine uptake in the rat returned towards normal when phenylbutazone was given for more than ten days. This was attributed to a saturation point following which the phenylbutazone could no longer bind the iodine and thyroidal accumulation of iodine then returned to normal levels.