K. P. Rao, S. Shaheen, M. Usha Rani
Dec 1, 1986
Citations
1
Influential Citations
7
Citations
Quality indicators
Journal
Toxicology letters
Abstract
Primidone, an anti-convulsant drug, was tested in mice for mutagenicity in somatic cells by the micronucleus test and in germ cells by the sperm-head abnormality assay. Mice were treated orally with the drug at doses of 4.37, 8.75 and 13.11 mg/mouse. The results indicate that the drug is capable of inducing mutations both in somatic and germ cells of mice.