Ma Wen-li
2008
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Journal of Shanxi Medical University
Abstract
Objective To explore the effect of S-bioallethrin on the gene expression profile of human lymphocytes.Methods Total RNA were extracted from peripheral blood lymphocytes treated by S-bioallethrin and hybridized with the Agilent human 1B 60mer oligonucleotide microarray,and then the changes of gene expression profile were studied.Results Changes of gene expression in 346 genes were found in human lymphocytes treated with S-bioallethrin,of which,16 genes related to immunity and defense and 1 gene related to apoptosis were down-regulated,and 6 genes related to apoptosis were up-regulated.Conclusion The total tendency of gene expression of human lymphocytes treated with S-bioallethrin is that some genes related to immunity and defense are down-regulated for promoting apoptosis and inhibiting proliferation.