Wu Gan-tong
2004
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Quality indicators
Journal
Journal of Shanghai Medica
Abstract
Purpose To study the inhibitory effect of thromboxane A 2 receptor antagonist,seratrodast(AA?2414) on the contraction of guinea-pig isolated tracheal strips and lung parenchyma strips induced by histamine,acetylcholine and KCl in vitro,and to compare it with short-acting β 2-receptor agonist salbutamol. Methods The following were measured and recorded by quantitative pharmacologic:(1) The contraction of guinea- pig tracheal strips induced by His,Ach and KCl before and after being incubated with se-ratrodast;(2) The contraction of guinea-pig tracheal strips induced by His,and KCl before and after being incubated with salbutamol;(3) the inhibitory effect of seratrodast and salbutamol on the contraction of guinea pig lung parenchyma strips induced by histamine. Results (1) His,Ach caused concentration-related contraction on the tracheal strips in vitro,seratrodast inhibited the contraction of tracheal strips induced by His,Ach;(2) Seratrodast and salbutamol inhibited the maximal contraction response induced by 60 mmol/L KCl;(3) Seratrodast and salbutamol had a significant inhibitory effects on contraction of lung parenchyma strips induced by histamine. Conclusions Seratrodast had a significant inhibitory effects on contraction of tracheal strips and lung parenchyma strips induced by asthmagenic meditors.It is an effective bronchodilator.