M. Habib, V. Watson, E. Schwartz
May 1, 1973
Citations
0
Influential Citations
8
Citations
Journal
Blood
Abstract
The incubation of peripheral blood with mained constant despite the reduction of sodium cyanate produced dose-related sup- total synthesis. The effects were also found pression of hemoglobin synthesis. Addition in peripheral blood and bone marrow of of 5 mM sodium cyanate reduced globin without hemoglobinopathies. The synthesis in the peripheral blood of a patient results suggest that further studies of the with sickle cell disease by 34#{176}/o, while 25 effect of cyanate on protein synthesis are mM cyanate reducedsynthesis by 92#{176}/o. The necessary before widespread use of the relative synthesis of a- and fl-chains re- drug in sickle cell disease.