Al-Nasiri A. Nazar, Al-Rahbi S. Omar, A. Khulood
Jun 1, 2005
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Quality indicators
Journal
Al Mustansiriyah Journal of Pharmaceutical Sciences
Abstract
This work describes the antimicrobial activity of newly synthesized 4-methyl (3-mercapto -4- phenyl -4H- 1,2,4-Triazole –5-yl) methyl piperazine. [1]. The newly synthesized piperazine derivative was obtained from basic cyclization of the intermediate product obtained from the reaction between acetic hydrizide –4-methyl piperazine and phenylisothiosyanate(1) .[1] The in vitro tests showed antimicrobial activity against two pathogenic bacteria viz; Staphylococcus aureus (gram positive) and Escherichia coli (gram negative), in addition to the dermatophyte pathogenic fungi Trichophyton rubrum. The screening antibacterial results illustrated below indicate that concentration [50mg/ml] showed the highest inhibitory effect against Escherichia coli, while the same concentration has a moderate activity againstStaphylococcus aureus.While the highest inhibitory effect against Trichophyton rubrum was achieved using the concentration [25 mg/ml].