G. Hakimelahi, A. Khalafi‐Nezhad
Nov 1, 1989
Citations
1
Influential Citations
22
Citations
Journal
Helvetica Chimica Acta
Abstract
A general and rapid procedure is developed for the preparation of secoribo-nucleoside analogues. Bu4NF has a marked effect on the condensation of guanine (5) with 2-(chloromethoxy)ethyl benzoate (2) or 1-halo-2-(chloromethoxy)ethanes 12 and 16. Condensation and deprotection of the acyl protecting group and nucleophilic displacement of the halogen atoms to yield 9-[(2-hydroxyethoxy)methyl] guanine (9) occurred in one step.