H. Yasuda, N. Izumi, O. Shimada
Mar 15, 1980
Citations
1
Influential Citations
47
Citations
Quality indicators
Journal
Toxicology and applied pharmacology
Abstract
Abstract The effect of tinoridine, an anti-inflammatory drug with a potent anti-peroxidative ability, on CCl 4 hepatotoxicity was investigated in rats. CCl 4 administration to rats produced not only marked increases in serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase but also decreases in liver microsomal cytochrome P -450 and glucose-6-phosphatase. These CCl 4 -induced alterations in the enzyme activities were markedly decreased by pretreatment with tinoridine. The protective effect of tinoridine was also ascertained by histologic evaluation. α-Tocopherol also showed a similar protection, but anti-inflammatory drugs such as phenylbutazone, indomethacin, ibuprofen, and prednisolone failed to protect against the CCl 4 -induced hepatotoxicity. These findings suggest that the anti-peroxidative action of tinoridine contributes to the protective effect against CCl 4 hepatotoxicity.