G. Cardinali, J. Blair
Dec 1, 1961
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0
Influential Citations
27
Citations
Quality indicators
Journal
Cancer research
Abstract
The effect of Vincaleukoblastine (VLB) on mitosis of normal bone marrow cells (DBA/2 mouse) and leukemic cells (L1210 leukemia) was studied. A single dose of VLB (1 mg/kg) injected intraperitoneally caused a metaphase arrest of cell divisions, in both normal bone marrow and leukemic cells. In the ascitic form of L1210 leukemia a transitory prophase inhibition was also produced.