S. Oftedal, K. Kayed
Nov 1, 1973
Citations
0
Influential Citations
29
Citations
Journal
Acta Radiologica
Abstract
ARNELL & LIDSTROM introduced Abrodil (methiodal sodium) for myelo graphy in 1931, but as experimental animals developed violent convulsions, ARNELL (1948) issued a strong warning against its use for ventriculography. Many authors agree with HOPPE (1959) who after extensive investigations of toxicity in animals concluded that iodinated water-soluble organic compounds should not be used for myelography or ventriculography in man. The introduction of Conray Meglumin (meglumine iothalamate) brought new interest in water-soluble contrast media for myelography. KODAMA et coll. (1963) stated that Conray Meglumin injected intravenously, intracerebrally and subarachnoidally in animals was considerably less toxic than other water-soluble media. They paid, however, little attention to its epileptogenic effect. This side effect has not often been considered in animal experiments. CAMPBELL et coll. (1964) who introduced Conray Meglumin for ventriculography and myelo graphy in man reported epileptic fits in one patient after its subarachnoid injec tion and concluded that transient muscle spasms and paresthesias limited its use for myelography. HEIMBURGER et coll. (1966 b) observed convulsions in a few human subjects following its intraventricular injection and in animal experiments