Paulina Liberman, Bryn M. Burkholder, J. Thorne
Sep 18, 2021
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Journal
American journal of ophthalmology
Abstract
PURPOSE To describe the effectiveness and side effect profile of difluprednate therapy in a series of patients with anterior scleritis. DESIGN Retrospective, interventional case series. METHODS Data collected from all patients with anterior scleritis who used difluprednate as a single treatment agent from 1/1/2018 to 1/1/2020 included: demographics, scleritis type, presence of nodules or necrosis, changes in scleritis activity, intraocular pressure (IOP), number of difluprednate drops used, best-corrected visual acuity (BCVA), and lens status. The primary outcome was clinical resolution of scleritis. Secondary outcomes included BCVA loss ≥ 2 lines, change in lens status or cataract surgery, and IOP ≥24 mm Hg. RESULTS Twenty-five patients (35 eyes) were analyzed. The median age was 60 years (range 13-78); 60% were female; 64% were Caucasian. Forty percent had bilateral disease; 44% of patients had an associated systemic disease. The majority of eyes (66%) had diffuse anterior scleritis. Eighty-three percent of eyes achieved resolution of scleritis, with a median time of resolution of 6 weeks. Eyes treated with an initial dose of ≥4 times daily were more likely to achieve disease resolution (hazard ratio [HR] = 3.43, 95% confidence interval [CI] 1.19, 9.88, p=0.02). Nine eyes had IOP elevation. Four eyes lost two lines or more of BCVA, one due to cataract progression. One eye underwent cataract surgery. CONCLUSIONS Difluprednate alone may effectively treat non-infectious anterior scleritis with a tolerable side effect profile.