J. Maj, H. Sowińska, L. Baran
Apr 1, 1974
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0
Influential Citations
37
Citations
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Journal
European journal of pharmacology
Abstract
Abstract The pharmacological action of 1,3-dimethyl-5-aminoadamantane (D145), a new adamantane derivative, was studied in rats. It increased strongly the motor activity in normal and hypoactive (following reserpine, α-methyltyrosine or FLA-63 pretreatment) animals. Catalepsy induced by spiroperidol, haloperidol, fluphenazine and reserpine (but not by chlorpromazine) was antagonized; the flexor reflex in spinal rats was not affected. D145 had no significant effect on noradrenaline or dopamine brain levels. The body temperature was slightly raised. D145 did not antagonize the effect of oxotremorine. In contrast to amantadine, but like apomorphine, D145 evoked hypotension which was prevented by spiroperidol or haloperidol. It is concluded that D145 activates the central dopamine neurons. The compound under studies differs from amantadine and in many (but not in all) respects acts like apomorphine.